Breast cancer grows faster during sleep

Breast cancer invades other organs in the final stages of the disease. Scientists have shown that circulating tumor cells are more aggressive at night while patients are asleep.

breast cancer most often manifests as a small, abnormal lump that grows larger as the disease progresses, eventually spreading to other organs. We’re talking about breast cancer metastatic. If the tumor goes on, duration The average life span of women with metastatic breast cancer is two to three years.

In order to metastasize, the primary tumor produces tumor cells that enter the bloodstream. These are the circulating tumor cells. They can then colonize anywhere in the body, making them difficult to detect, but in the specific context of breast cancer, it’s the bones, the lungs, the liver and the brain that are most commonly affected.

The mechanisms that lead to the formation of the primary tumor metastases remain largely in the dark. Some scientists believe they are produced continuously or as a result of damage physically or mentally. Swiss researchers from the Universities of Basel and Zurich have obtained surprising results that call this into question postulate. Her work has appeared in Nature A few days earlier.

More aggressive tumor cells at night

In fact, their research was conducted on mice or humans breast cancer shows that circulating tumor cells experience an “activity spurt” during sleep. They are more likely to form metastases than those formed during the day. This observation was made possible thanks to the analysis of RNA expressed by every circulating tumor cell.

RNAs – molecules mediator betweenDNS and proteins – reflect the activity of a cell at a time T. The circulating tumor cells express theirs very strongly at night Genoa Mitotica, which allow them to divide. This intense mitotic activity was observed exclusively during the night and is the origin of the considerable metastatic capacity of the circulating tumor cells formed at night.

What happens in our body before bed to have such an effect on circulating tumor cells? Researchers believe hormones are involved in this story. That melatoninthe sleep hormone, but also that testosterone and glucocorticoids, hormones circulating in the blood that affect, among other things, carbohydrate metabolism, dictate the production dynamics of circulating tumor cells. In summary, the production of circulating tumor cells with high metastatic potential is not continuous, but is only concentrated at night.

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