How diet causes prostate cancer or not

THE ESSENTIAL

  • Saturated fats also contribute to the increase in bad cholesterol, LDL, in the blood.
  • They are particularly found in animal fats, fatty meat and eggs.
  • Prostate cancer is most common in France, with around 50,000 new cases per year.

Health also goes through the plate. A study published in Nature communication proves it once more. Their authors were interested in the effects of a diet high in saturated fats on cancer progression. They note that this type of diet contributes to the growth of tumors due to the expression of a specific gene.

Greater growth of tumors

The MYC gene, which is overexpressed in certain cancers, was observed by the researchers in this work done in mice. Two types of experimental animals were used: mice”normal” and prostate cancer-prone mice overexpressing the MYC gene. Two diets were tested in each of these two groups: one high in fat and one more traditional. The high-fat diet was associated with more obesity and mild diabetes in both types of mice. In those with overexpression of the MYC gene, this also led to more tumor growth, which also became more aggressive.

For the authors, these episodes are consecutive to “epigenetic changes”. Overexpression of MYC, coupled with a high-fat diet, blocks the addition of methyl groups to DNA, which normally serve to reduce the expression of cancer-promoting genes. “A high-fat diet causes metabolic and epigenetic changes that promote cancer cell growth and contribute to higher mortality from prostate cancer.”closes dr Massimo Loda, study co-author and chair of the Division of Laboratory Medicine at Weill Cornell Medicine in New York.

Similar compounds found in humans

The research team then wanted to understand whether these dietary changes are valid in humans. To do this, the various authors analyzed the data and samples from 319 patients with prostate cancer, including their responses. to nutrition questionnaires. Patients on a high-fat diet, whether obese or not, had higher expression of MYC-related cancer genes and had a higher risk of dying from their cancer compared to patients on a low-fat diet.

Before the study,IMost of these patients did not have overexpression of MYC“, the authors state. This implies that a high-fat diet alone was sufficient to promote tumor progression.”Changing the patient’s diet, you can reduce the aggressiveness of the tumor“, believes Dr. Massimo Loda. In mice, switching from a high-fat diet to a low-fat diet had positive effects on cancer. More studies are needed to confirm these results in humans.

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