Revealing the obscure and surprising effects of certain painkillers on the human body

Without excess, painkillers are considered completely harmless. However, a study has shown that while pain relievers are effective for certain health conditions, some of them have unexplained and potentially dangerous health effects.

Analgesic, painkiller, NSAID: what is it?

Analgesics, also known as painkillers or analgesics, are medications used to treat pain. dolipran, efferalgan, dafalgan, ibuprofen; There are a very large number of brands of pain relievers on the market. Although many brands are similar, you should know that there are different types of pain relievers and the World Health Organization (WHO) classifies them according to the intensity of pain they can treat. Generally, three types of analgesics are considered, and the most commonly used is “Stage 1”.

Level 1 pain relievers are drugs used to treat mild and common pain, including acetaminophen-based drugs and nonsteroidal anti-inflammatory drugs (NSAIDs). Most level 1 pain relievers can be purchased over the counter without a prescription, but that doesn’t mean they’re safe. In fact, a new study by Yale University researchers has shown that some of these drugs can have surprising side effects on the human body.

Discovery of a new mechanism of action for NSAIDs

According to the results of the study published in the journal immunity, some NSAIDs can have adverse effects on serious diseases such as cancer and heart disease, while others have been linked to a reduced incidence of the same diseases. To better understand this, researchers have re-examined how these drugs work. Until now, researchers believed that the anti-inflammatory effects of NSAIDs were solely due to the inhibition of certain enzymes.

But this mechanism does not take into account many clinical outcomes that vary from one drug family to another. To further advance their research, the scientists conducted experiments on cell cultures and mice. In particular, they discovered a specific mechanism by which a subset of NSAIDs reduces inflammation. In particular, this mechanism is linked to a protein called NFR2. When activated, this protein protects the body cells from damage caused by oxidative stress and thus prevents inflammatory processes.

Thus, while this new mechanism explains the anti-inflammatory effectiveness of some NSAIDs, it does not explain why others have adverse health effects. According to the researchers, more studies should be done on the subject as it could radically change the use and regulations surrounding NSAIDs. ” Because people use NSAIDs so frequently, it is important that we know what they do to the body. ” explained in particular Anne Eisenstein, lead author of the study, in a statement. Additionally, these studies are also needed to find more effective ways to use these drugs to treat diseases like allergies and autoimmune diseases.

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