One in 500 men carries an extra sex chromosome

The XX or XY chromosomes define a person’s sex, but in a significant proportion of men, one can be too many. Individuals XXY or XYY would then be exposed to different health problems, according to a recent study conducted at Cambridge University.

Human genetic heritage is condensed into 23 pairs of chromosomes, one of which is responsible for gender: XX for females and XY for males. But, According to researchers at the University of Cambridgea non-negligible percentage of men has a chromosomal abnormality.

In fact, after analyzing medical data from the BioBank UKthey showed that about one in 500 men has a chromosome sexual, X or Y and more! So these affected men do not have 46 chromosomes, but 47 with a sex signature XXY or XYY. Without making one karyotype, this anomaly often goes unnoticed. Only 23% of the 47XXY men who participated in this study knew of its existence, and 0.7% of 47XYY. However, Cambridge scientists have shown this chromosome Excess could contribute to certain health problems.

An additional sex chromosome favors the occurrence of certain diseases

47XXY men can sometimes be diagnosed during puberty. In fact, this anomaly is known as syndrome von Klinefelter and tends to delay puberty in adolescents and cause problemsinfertility in adults. 47XYY males are often taller than average, but beyond that there is no evidence that the anomaly exists in them.

Although a significant number of men Goal an extra sex chromosome that few are likely aware of. That extra chromosome means they’re at significantly higher risk of a number of common metabolic, vascular, and respiratory diseases — diseases that are potentially preventable », explains Yajie ZhaoFirst author of the study.

By making the link between their chromosomal peculiarity and the health problems the 356 men, ages 40 to 70, developed during follow-up, the scientists were able to do so bright the phenotypes XXY and XYY increase the risk of type 2 diabetes,pulmonary embolismand from Chronic obstructive pulmonary disease also called COPD. A genetic test may allow the anomaly to be identified “quite easily,” observes Ken Ong, a scientist on the same research team. It could become a risk factor to be taken into account in the medical aftercare of the affected patients.

Interested in what you just read?

Leave a Comment