In cancer, healthy cells turn into malignant cells with completely different properties, such as the ability to divide uncontrollably. In the treatment of leukemia, researchers have achieved promising results by artificially engineering the reverse biological phenomenon.
This new hope in the fight against cancer is the result of a research program carried out jointly by Spanish and Israeli teams. The conversion of leukemia cells into harmless cells could become a new treatment protocol for oncologists and hematologists in the fight against cancer.
If the opposite phenomenon is already known, researchers have discovered that it was possible, by chemically modifying a cell, thus continuing the technique of epigenetics, that is, by treating its genetic material, called messenger RNA, in a particular way altering genetic makeup nature.
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Until now, scientists knew very little about the reverse process: the possibility of reversing a cancer cell, turning it back into a non-cancerous physiological cell, and what factors might influence this process.
The researchers therefore wanted to know more about the molecular pathways involved in this cellular transformation. They therefore studied an in vitro model in which a leukemia cell was treated to become a type of harmless immune cell called a macrophage.
Epigenetic processes allow the same DNA to be used differently from cell to cell. They do not change the genes, but they can silence them or, on the contrary, make them available, that is, make them accessible to the machinery that makes it possible to read them. This is accomplished through a variety of strategies, including the addition of small chemical groups.
The investigation, published by the revista leukemia, which han llevado a cabo Alberto Bueno-Costa, investigator of the group of Manel Esteller, head of the studio and director of the Instituto español… https://t.co/PAKGMA6fdl
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In the past few decades, numerous scientific studies have been able to discover various molecular changes that are responsible for this transformation of healthy tissue into a tumor.
In leukemia, as in cancer, healthy cells become malignant with very different properties, such as the ability to divide uncontrollably.
Although this research program has not yet been tested in patients, the research team believes that the initial results appear sufficiently promising to merit further investigation as a new approach in the fight against leukemia.
“The first preclinical drugs against this target have already been developed in experimental models of malignant blood diseases”, points in particular to the study. These new drugs could prove revolutionary in cancer therapy, particularly in leukemia and lymphoma.