77 cases in France, symptoms, is it dangerous?

Derived from Delta and Omicron (formerly “Deltacron”), the XD variant is a recombinant of the Covid virus. It is said to have infected 77 people in France, but is no more dangerous than the Omicron BA.2 variant. What are the symptoms of the XD variant? Is it (more) dangerous? Know everything.

One can be infected with two variants of Covid the same time. that Variant XD is a recombinant by Delta and Omicron (formerly “Delta Crown”). Recombinant XD is always detected at low levels (0.2% during the Flash Week 16 survey (April 18-24) and not detected at week 17 (April 25 – May 1, 2022)” written down Public Health France in the epidemiological update of May 12. 77 XD variant infections were studied by the regional units of Public Health France according to the risk analysis of April 20th. Eight hospitalizations but were reported no cases of critical care or death with the XD variant. “This recombinant is detected in France in very small amounts, which speaks for a no competitive advantage of this variant compared to Omicron BA.2. Other Delta/Omicron recombinants, named XF and XShave occurred in other countries under similar circumstances“indicates the health organization. How many cases exactly in France? What profiles? Rather young people or elderly? How to tell if you have the XD variant ? What are the symptoms typical? More dangerous what omicron? The latest info.

Definition: What is the XD variant?

“If two variants are in circulation at the same time, some can do that can be infected with two variants at the same time. These co-infections can lead to recombination phenomenaThat means Exchange of genetic material between the two variantsremembers Public Health France. The recombinant therefore has a genome which corresponds in part to that of the first variant and in part to that of the second variant. that Variant XD was first detected in early January 2022, it is actually a recombinant Because he has genetic characteristics of the two parental VOCs (variants) Delta and Omicron (BA.1)” informed Public Health France in its risk analysis of March 25. “that Pangolin line XD was assigned to this recombinant and is now the official name for it recombinant (formerly Deltacron).” This variant was classified as VUM (Variant Under Monitoring), ie “Variant under examination”. The phenomenon of recombination is common in SARS-CoV-2 and its public health importance depends on the similarity of characteristics (transmissibility, pathogenicity, immune escape) between the two parent variants:

►If they have different properties, such as B. Delta and Omicron, Increased surveillance is essential to determine the properties of the recombinants (transmissibility, pathogenicity, immune escape) that are likely to change the dynamics of the COVID-19 epidemic.
► The more similar the parental variants are, the less likely it is that a recombinant will have different properties.

“No case of the XD variant has affected people over 70”

How many cases of XD variant in France?

In France, between December 2021 and January 2022, the Delta/Omicron co-circulation has been associated with the emergence of the XD recombinant. From April 15th 77 cases of infection with the XD variant (54 confirmed cases and 23 suspected cases not sequenced but linked to a confirmed case) were investigated by the regional units of Public Health France. These sequences correspond to cases from multiple regions. The XD variant thus represents less than 0.1% of the interpretable sequences. “The median age of the cases was 37 years, with the youngest case being 4 years old and the oldest being 86 years old. The average age was similar to Omicron infection casesexamined between November 2021 and January 2022″. Six cases of infection with the XD variant reported a previous infection by SARS-CoV-2 (8.1%), i.e. a lower proportion than in cases of infection by Omicron (14%).

What are the symptoms of the XD variant?

According to Public Health France, the The most common symptoms seen in people infected with the XD variant are: Asthenia/Fatigue (58%), headache (56%), Fever (46%), Cough (42%) and Sore throat (38%). The main difference from the cases of omicron infection studied so far is the higher rate ageusia [perte du goût] and anosmia [perte d’odorat].

Symptoms of the 77 cases of infection with the XD variant compared to the cases of infection with Omicron investigated so far. 04/20/2022 © Public Health France

These recombinants are difficult to detect because we do not know at first glance whether it is a co-infection or a hybrid. This is high-flying work in genomics.and“indicates Professor Bruno Lina, virologist, on Tuesday March 1, 2022 at France Inter. The first cases of co-infections and recombination occurred during the sequencing performed during the flash surveys.In France, increased surveillance of Delta/Omicron coinfections has been established to detect possible recombinants as early as possible” added Public Health France. Before you remember the context: “Since the end of 2021, an omicron wave has been superimposed with a delta wave in several regions of the world. This large-scale co-circulation of two variants increases the likelihood of co-infections and hence recombinants. Several putative Delta/Omicron recombinants have recently been reported in the UK, USA and Australiaand others are under investigation“.

Is the XD variant more dangerous than Omicron?

According to observations by the health authorities, the XD variant is not associated with a higher level of danger than the Omicron variant or the Delta variant. Eight hospitalizations were reported among the cases of XD variant infection studied, four of which were part of a hospital cluster and were hospitalized for a reason other than COVID-19. “No emergency rooms and no deathss have been reported but longitudinal follow-up would be required to confirm this“reports Santé Publique France on April 20.”This recombinant is detected in France in very small amounts, which speaks for a lack of competitive advantage of this variant compared to Omicron BA.2‘ adds the health organization.

Sources:

– Risk analysis related to emerging variants of Sars-Covid-2, April 20, 2022, Santé Publique France.

– Coronavirus: spread of SARS-CoV-2 variants updated on March 23, 2022, Public Health France.

– Flash surveys: assessment of the spread of SARS-CoV-2 variants in France, updated on February 28, 2022, Public Health France.

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