the stool transplant, the miracle cure for aging?

Could our intestinal flora be a real fountain of youth? In search of eternal youth it seems so Transplanting the fecal microbiota is one way to combat aging. According to a recent English study published in the journal on April 29 microbiometransplanting fecal microbiota from young mice to older mice reversed the signs of aging in the gut, eyes and brain.

In light of this study, stool transplants could be considered a way to reverse the aging process. Scientists from the Quadram Institute and the University of East Anglia, England, who carried out this work, instead provided evidence that transplanting gut microbes from old mice causes inflammation in the brains of young recipients and depletes a key protein necessary for normal vision .

Stool Transplant: Reverses harmful changes in the gut, eye, and brain

Chronic age-related inflammation has actually been linked to the activation of specific immune cells in the brain. These cells were also overactivated in young mice that received aged microbiome transplants. In the eye, the team also found that specific proteins associated with retinal degeneration were elevated in young mice given microbiota from older mice.

In fact, for the better understand the impact of changes in the gut microbiota on the aging processthe scientists transferred gut microbes from old mice to healthy young mice and vice versa. They then examined the effects of these modifications on the inflammatory signs of aging in the intestines, brain and eyeswhose functions decline with age. So they found out that the Transplantation of microbiota from aged mice resulted in loss of gut wall integrity in younger people, allowing bacteria to pass through the circulatory system, which in turn triggers the immune system and inflammation in the brain and eyes.

Gut: Microbes regulate certain harmful effects of aging

In older mice, however, these adverse changes can occur in the gut, eye, and brain reversed by transplantation of gut microbiota from young mice. The microbiota of young mice and old mice that received young microbiota transplants were indeed enriched in beneficial bacteria that have previously been associated with good health in both mice and humans.

These results show that the Gut microbes may play a role in regulating some of the adverse effects of aging and pave the way for therapies based on gut microbes to combat decline later in life. “This landmark study provides insight into how gut microbes regulate some of the adverse effects of aging Evidence for the direct involvement of gut microbes in the aging process and functional decline of the brain and vision and provides a possible solution in the form of gut microbe replacement therapy‘ explains Professor Simon Carding of UEA’s Norwich Medical School and Director of the Gut Microbes and Health Research Program at the Quadram Institute.

Hope for degenerative eye and brain diseases

“We were thrilled to find that we could achieve this by altering the gut microbiota of older people sure indicators of age-related declinecommon in degenerative eye and brain diseases,” said the study’s lead author, Dr. Aimee Parker of the Quadram Institute manipulate our diet and gut bacteria to maximize health in old age”.

If this study was done in mice, similar pathways exist in humans and the The human intestinal flora also changes significantly with age, but the researchers caution against extrapolating their findings directly to humans until similar studies are done in older people. A new facility for microbiota replacement therapy, also known as fecal microbiota transplantation, is being built at the Quadram Institute, which will facilitate such studies, as well as other studies for related diseases.

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