Stool transplants reverse signs of aging in mice

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[EN VIDÉO] The gut microbiota, a valuable ally for our health
There are different microbiota in the body: those of the skin, mouth, vagina… But the most important one is the gut microbiota. Scientists have long known of their potential, but the development of new techniques allows research to deepen to describe the nature of the interactions between host and microbiota, that of microorganisms between them and their impact on health.

What if the bacteria that live in our gut were a way to fight aging? That transplantation from microbiota a young mouse in an old mouse can reverse age-related inflammation Brainretina and gut of rodents corresponding a new study published in microbiome. It is not the first time that a graft of microbiota makes it possible to “rejuvenate” mice.

The microbiota reduces age-related inflammation

In this case, the scientists first killed the recipient mice’s microbiota before giving them fecal pellets containing the microbiota of a younger or older mouse. They also analyzed markers of inflammation in the brain, retina and gut of transplanted mice. When a young mouse is transplanted with a microbiota from an older rodent, it shows inflammation characteristic of old age. Conversely, an old mouse grafted with the microbiota of a young animal will see these traits reabsorbed.

The implications of this research are still unclear, but scientists believe so modulations of the microbiota could prevent the inflammatory problems associated with aging. More research is needed to estimate the long-term benefits these microbiota transplants on animal health and ultimately on human health.

Stool transplant rejuvenates mice

Article byEleanor Sole published on August 15, 2021

In mice, transplanting a fecal microbiota from a young mouse to an old mouse appears to ‘rejuvenate’ certain abilities of that mouse.

About two kilograms microorganisms live in our digestive system, after whichInsert. Out of virusBacteria, Mushrooms and parasites that affect our health, including our immune and neurological functions. A new study published in aging in naturesuggests that this microbiome could be a relevant therapeutic target to promote healthy aging.

A find from transplants from microbiota feces. The donors were mice, either 3-4 months old or 19-20 months old, while the recipients were systematically 19-20 months old. Only transplants from young mice were effective. They have ” reverse aging differences However, the authors also write about some aspects of immunity subdued cognitive impairments associated with age.

All in good time

previous research […] have shown that the microbiome Gut plays a key role in the aging and the aging process recalls John Cryan, co-author of the study. This new research could be a game changer, as we found that the microbiome can be harnessed to reverse age-related brain deterioration. We also see evidence of improved learning ability and cognitive function. »

These results could have important implications for the geriatrics or the prevention out of symptoms of aging. But he is ” still early ‘ John Cryan warns against projecting yourself into it applications Therapies: Much more work is needed to see how these results translate to humans. »

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